Tales From The Crypt
Tales From The Crypt #5
Twin siblings Carl and Cynthia Dunn always looked a lot like each other. Down on his luck, Carl decides to kill both Cynthia and her wealthy husband, and then impersonate her to inherit the money. He would have gotten away with it too, if it weren't for those nosy kids and their dog. (Well, not quite...but he does make one teensy little mistake.)
Haunt of Fear
Haunt of Fear #26
Janet and Leon were madly in love, but they had one problem. Janet's husband is a mad surgeon with a really twisted sense of justice.
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3-D Zone
3-D Zone #16
Colorized picture donated by Paul Pichette
Newlyweds Brick and Connie travel to a frontier planet for their honeymoon,
but Connie eventually leaves after becoming tired of Brick's chauvanistic
behavior. She returns a few months later to discover that Brick's chauvanistic
attitudes have been corrected.
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The Better Half
Big Bang Comics #21
Mike and Jenny are the perfect couple...inseparable. Unfortunately, the vampire Victor Vargos agrees, so he arranges for the pair to really be inseparable.
"Color Queen"
Legion of Substitute Heroes Special #1
Infectious Lass infects Color Kid with "Grandin Gender Reversal
Disease," causing him to change into a woman overnight. Of course,
they didn't even realize the change was her fault until she infects six
shuttle passengers and a customs clerk (off-camera). Hey, what do you
expect from the Legion of Substitute Heroes, anyway? 
Cover
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Matter-Eater Lass
Legionnaires #13-14
The "Grandin Gender Reversal Disease" makes another appearance. This time, it's given to Matter-Eater Lad so he can infiltrate a gang of female pirates. Unfortunately, his performance is less than convincing...
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Shvaughn/Sean Erin
Legion of Super-Heroes #31
Shvaughn Erin has had a long-time crush on Jan Arrah (Element Lad). To give her a chance at winning his love, she has been taking a sex-changing drug called Profem since she was a teenager. Unfortunately, with Profem no longer available, Shvaughn finds herself transforming back into Sean.
Alien Encounters
Alien Encounters #11
Two guys crash land on a planet apparently inhabited only by females. They soon discover there's a reason why there are only women around...
In a comic book adaptation of Graham Masterton's "Changeling" story, a man has sex with a woman and wakes up to discover that they have switched bodies.
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Chondu
The Sensational She-Hulk #3
During a battle with the "Head Men" (don't worry...nobody else has heard of them, either), She-Hulk is knocked unconscious, and Chondu's head is placed on her body. (It was a vast improvement over his old body with the tentacles, bat wings and bird's feet, but strangely he doesn't see this as much of a trade-up. Go figure.)